Identification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer
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منابع مشابه
Identification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer
BACKGROUND Protein glycosylation is an important post-translational modification shown to be altered in all tumour types studied to date. Mucin glycoproteins have been established as important carriers of O-linked glycans but other glycoproteins exhibiting altered glycosylation repertoires have yet to be identified but offer potential as biomarkers for metastatic cancer. METHODOLOGY In this s...
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Progress in treatment for cancer has enabled extension of the disease-free interval, and of the quality of life for patients, but there has been very little improvement in overall survival rates. The main reason for this has been the ineffectiveness of current therapies to kill all the cancer cells once they have spread to distant sites to form metastatic deposits. One marker which has proved t...
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Altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. Lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. The aim of the present study was to identify the N-acetylgalactosamine (GalNac) containing glycoconjugates in cancer cells in a...
متن کاملlectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin
altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells. lectins are nonimmunogenetic compounds which specifically detect certain terminal sugars of glycoconjugates. the aim of the present study was to identify the n-acetylgalactosamine (galnac) containing glycoconjugates in cancer cells in a...
متن کاملBiochemical and Structural Analysis of Helix Pomatia Agglutinin (hpa): a Hexameric Lectin with a Novel Fold*
AGGLUTININ (HPA): A HEXAMERIC LECTIN WITH A NOVEL FOLD* Jean-Frederic Sanchez, Julien Lescar, Valérie Chazalet, Aymeric Audfray, Jean Gagnon, Richard Alvarez, Christelle Breton, Anne Imberty & Edward P. Mitchell From Centre de Recherches sur les Macromolécules Végétales, CNRS (affiliated with Université Joseph Fourier), Grenoble, France, School of Biological Sciences, Nanyang Technological Univ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0138345